Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200049 | 1.00 | CHRNB2 (0.30) | CHRNB2CHRNA4 | |
| SCHEMBL23563100 | 0.79 | ALOX5AP (0.32) | — | |
| SCHEMBL30015455 | 0.79 | ALOX5AP (0.32) | — | |
| SCHEMBL13010773 | 0.79 | TSHR (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL1534916 | 0.78 | — | — | |
| SCHEMBL17804168 | 0.76 | DGAT1 (0.36) | — | |
| SCHEMBL30043054 | 0.75 | TNKS (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL746530 | 0.75 | TNKS (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL24129962 | 0.75 | PDE2A (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL1554553 | 0.75 | MBOAT4 (0.33) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |
| EP-4255573-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |