Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 5/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22936262 | 0.77 | CD38 (0.47) | JAK2CD38 | |
| SCHEMBL300814 | 0.75 | IKBKB (0.47) | MAPK1CD38PDPK1IKBKBCHUK | |
| SCHEMBL29696570 | 0.71 | PDPK1 (0.40) | MAPK1KDRCD38PDPK1IKBKB | |
| SCHEMBL22936261 | 0.71 | CD38 (0.69) | CD38 | |
| SCHEMBL28741959 | 0.66 | METAP2 (0.61) | LRRK2MAPK1METAP2IDO1KEAP1 | |
| SCHEMBL29626795 | 0.65 | METAP2 (0.63) | METAP2KDM4EKDM4AKDM5CKDM4C | |
| SCHEMBL28741907 | 0.65 | METAP2 (0.63) | METAP2KDM4EKDM4AKDM5CKDM4C | |
| SCHEMBL29494927 | 0.64 | DYRK1A (0.50) | MAPK1PDPK1IKBKBCHUK | |
| SCHEMBL29495219 | 0.63 | CD38 (0.55) | LRRK2KEAP1CD38LATS1 | |
| SCHEMBL29882414 | 0.60 | PDPK1 (0.45) | LRRK2KEAP1JAK2PAK4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003980-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | Ribon Therapeutics Inc. (US) | 2022-06-01 | — | — | EP | claimed |
| EP-4003980-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | Ribon Therapeutics Inc. (US) | 2022-06-01 | — | — | EP | disclosed |