Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542761 | 0.83 | EPHX2 (0.46) | ALDH1A1L3MBTL1 | |
| SCHEMBL1542717 | 0.79 | POLB (0.61) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPC1 | |
| SCHEMBL12678698 | 0.79 | PLK1 (0.49) | HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL24243468 | 0.79 | ALDH1A1 (0.46) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL8953866 | 0.77 | PRSS1 (0.48) | ALDH1A1L3MBTL1PRSS1SMN1; SMN2MAPK1 | |
| SCHEMBL17315503 | 0.77 | PRSS1 (0.48) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL10694847 | 0.76 | SMN1; SMN2 (0.54) | HDAC1ALDH1A1L3MBTL1PRSS1SMN1; SMN2 | |
| SCHEMBL8602089 | 0.76 | PRSS1 (0.47) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL13985099 | 0.75 | PDK1 (0.58) | ALDH1A1L3MBTL1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL13985100 | 0.75 | NPC1 (0.59) | HDAC8HDAC6KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267553-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140520-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |