Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313742 | 0.88 | OPRK1 (0.54) | OPRK1PDE4DLMNAGABRA1GABRG2 | |
| SCHEMBL7351309 | 0.86 | CCKBR (0.42) | OPRK1CCKBR | |
| SCHEMBL11538446 | 0.85 | CYP3A4 (0.49) | CYP3A4OPRK1DRD3PDE4DSLC22A1 | |
| SCHEMBL7317188 | 0.85 | OPRK1 (0.50) | CYP3A4OPRK1DRD3PDE4DSLC22A1 | |
| SCHEMBL7305688 | 0.84 | OPRK1 (0.55) | OPRK1PDE4DKCNH2LMNAGABRA1 | |
| SCHEMBL7313961 | 0.84 | TP53 (0.40) | CYP3A4OPRK1DRD3PDE4DSLC22A1 | |
| SCHEMBL7381138 | 0.82 | CYP3A4 (0.48) | CYP3A4OPRK1DRD3PDE4DSLC22A1 | |
| SCHEMBL7383459 | 0.82 | CCKBR (0.41) | CYP3A4OPRK1DRD3PDE4DSLC22A1 | |
| SCHEMBL11541903 | 0.81 | CHRM1 (0.49) | CYP3A4OPRK1DRD3PDE4DSLC22A1 | |
| SCHEMBL11546114 | 0.81 | LMNA (0.49) | CYP3A4OPRK1DRD3PDE4DSLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776852-B2 | Process for producing highly pure midazolam and salts thereof | CHEMAGIS LTD. (IL) | 2010-08-17 | — | — | US | disclosed |
| US-7776852-B2 | Process for producing highly pure midazolam and salts thereof | CHEMAGIS LTD. (IL) | 2010-08-17 | — | — | US | disclosed |
| US-7776852-B2 | Process for producing highly pure midazolam and salts thereof | CHEMAGIS LTD. (IL) | 2010-08-17 | — | — | US | disclosed |
| US-20090069306-A1 | PROCESS FOR PRODUCING HIGHLY PURE MIDAZOLAM AND SALTS THEREOF | CHEMAGIS LTD. (IL) | 2009-03-12 | — | — | US | disclosed |
| US-20090069306-A1 | PROCESS FOR PRODUCING HIGHLY PURE MIDAZOLAM AND SALTS THEREOF | CHEMAGIS LTD. (IL) | 2009-03-12 | — | — | US | disclosed |
| US-20090069306-A1 | PROCESS FOR PRODUCING HIGHLY PURE MIDAZOLAM AND SALTS THEREOF | CHEMAGIS LTD. (IL) | 2009-03-12 | — | — | US | disclosed |
| US-4440685-A | MUSCLE RELAXANTS, SEDATIVES, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4425272-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1984-01-10 | — | — | US | disclosed |
| US-4401597-A | INTERMEDIATES FOR ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVE AND ANXIOLYTICS | HOFFMANN-LA ROCHE INC. (US) | 1983-08-30 | — | — | US | disclosed |
| US-4390471-A | INTERMEDIATES FOR IMIDOBENZODIAZEPINE AND ANALOGS | HOFFMANN-LA ROCHE INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4368157-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4349476-A | IMIDAZO/1,5-A//1,4) BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINE | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349477-A | IMIPAZO/1,5-A//1,4/BENZO-, THIENO- OR PYRAZOLODIAZEPINES FROM 2-DIMORPHOLINOPHOSPHONATES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349475-A | IMIDAZO/1,5-A//1,4/BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZOTHIENO-OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4347365-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4347364-A | INTERMEDIATES THEREFOR | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4307237-A | ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| US-RE30473-E | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4105852-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069306-A1 | PROCESS FOR PRODUCING HIGHLY PURE MIDAZOLAM AND SALTS THEREOF | CYP3A4, CYP3A43, CYP3A5 | CYP3A4 1/4885OPRK1 115/4885DRD3 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.