Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.59 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.59 |
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30023801 | 0.83 | NOTUM (0.58) | PRMT5WDR77ACENOTUMABHD6 | |
| SCHEMBL15355424 | 0.82 | PRMT5 (0.67) | PRMT5WDR77ACENOTUMABHD6 | |
| SCHEMBL16268868 | 0.82 | ALDH1A1 (0.64) | PRMT5WDR77ACENOTUMABHD6 | |
| SCHEMBL30647004 | 0.81 | PRMT5 (0.55) | PRMT5WDR77ACENOTUMABHD6 | |
| SCHEMBL15355387 | 0.81 | PRMT5 (0.55) | PRMT5WDR77ACENOTUMABHD6 | |
| SCHEMBL9527451 | 0.81 | PRMT5 (0.57) | PRMT5WDR77ACENOTUMABHD6 | |
| SCHEMBL9853000 | 0.80 | SMN1; SMN2 (0.58) | PRMT5WDR77NOTUMABHD6MEN1 | |
| SCHEMBL3721168 | 0.79 | PRMT5 (0.56) | PRMT5WDR77NOTUMABHD6HRH3 | |
| SCHEMBL22032274 | 0.79 | PRMT5 (0.61) | PRMT5WDR77NOTUMABHD6MEN1 | |
| SCHEMBL324836 | 0.78 | PRMT5 (0.55) | PRMT5WDR77NOTUMABHD6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829555-A | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116332873-A | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114025844-B | Protein tyrosine phosphatase inhibitors and methods of use thereof | 卡里科生命科学有限责任公司 | 2022-07-26 | — | — | CN | disclosed |