Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.39 |
| ▸ | NOS2 | P35228 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | NCK1 | P16333 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21223738 | 1.00 | BACE1 (0.39) | BACE1NOS2NOS3NOS1MCHR1 | |
| SCHEMBL25216953 | 0.78 | PDE5A (0.30) | — | |
| SCHEMBL30456317 | 0.78 | PDE5A (0.30) | — | |
| SCHEMBL29911849 | 0.78 | BACE1 (0.39) | BACE1NOS2NOS3NOS1NCF1 | |
| SCHEMBL20971414 | 0.78 | BACE1 (0.36) | BACE1NOS2NOS3NOS1MCHR1 | |
| SCHEMBL25927973 | 0.76 | CCR1 (0.37) | — | |
| SCHEMBL15091354 | 0.76 | NOS2 (0.54) | BACE1NOS2NOS3NOS1MCHR1 | |
| SCHEMBL23841691 | 0.76 | NOS2 (0.38) | BACE1NOS2NOS3NOS1MCHR1 | |
| SCHEMBL31661251 | 0.74 | NOS3 (0.37) | BACE1NOS2NOS3NOS1MCHR1 | |
| SCHEMBL20326201 | 0.74 | NOS3 (0.37) | BACE1NOS2NOS3NOS1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010328-A1 | 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Domain Therapeutics (FR) | 2022-06-15 | — | — | EP | disclosed |