Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 11/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372852 | 1.00 | ADRB1 (0.36) | ADRB1HDAC4CFTRHDAC6PRKCB | |
| SCHEMBL2372856 | 1.00 | ADRB1 (0.36) | ADRB1HDAC4CFTRHDAC6PRKCB | |
| SCHEMBL29699237 | 0.73 | DRD2 (0.46) | — | |
| SCHEMBL2372239 | 0.73 | DRD2 (0.46) | — | |
| SCHEMBL2372244 | 0.73 | DRD2 (0.46) | — | |
| SCHEMBL4828955 | 0.72 | ADRB1 (0.38) | ADRB1 | |
| SCHEMBL4828950 | 0.72 | ADRB1 (0.38) | ADRB1 | |
| SCHEMBL14784270 | 0.70 | CFTR (0.42) | CFTR | |
| SCHEMBL2373230 | 0.70 | HDAC4 (0.41) | HDAC4HDAC6 | |
| SCHEMBL29699276 | 0.70 | CD274 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |