Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25225128 | 0.80 | KDM4E (0.45) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9953506 | 0.75 | PARP1 (0.50) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29699541 | 0.75 | PABPC1 (0.56) | KDM4ESMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL7452418 | 0.71 | KDM4E (0.49) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28276095 | 0.70 | PRKCI (0.63) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL5902495 | 0.69 | PARP1 (0.50) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29082826 | 0.69 | P2RX7 (0.62) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28151967 | 0.68 | POLB (0.50) | KDM4ERAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL7451831 | 0.67 | KDM4E (0.46) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7452205 | 0.67 | KDM4E (0.52) | KDM4EP2RX7RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115175908-B | Aryl or heteroaryl pyridone or pyrimidinone derivatives, and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2024-07-23 | — | — | CN | disclosed |
| US-20230118795-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | SUZHOU ZELGEN BIOPHARMACEUTICALS CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| EP-4092026-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2022-11-23 | — | — | EP | disclosed |
| CN-115175908-A | Aryl or heteroaryl pyridone or pyrimidone derivative and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| WO-2022135591-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDONE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-06-30 | — | — | WO | disclosed |
| CN-114671866-A | Aryl or heteroaryl pyridone or pyrimidone derivative and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-06-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230118795-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | KRAS, NRAS, HRAS | KDM4E 2612/4885P2RX7 964/4885RAB9A 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.