Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15407009 | 0.77 | HDAC3 (0.59) | PABPC1EIF4HCA1CA2SMN1; SMN2 | |
| SCHEMBL28276095 | 0.76 | PRKCI (0.63) | MAPTHTTKDM4EALDH1A1GLA | |
| SCHEMBL4436754 | 0.75 | KDM4E (0.47) | PABPC1EIF4HCA1CA2CA9 | |
| SCHEMBL29699513 | 0.75 | KDM4E (0.44) | PABPC1EIF4HCA1CA2SMN1; SMN2 | |
| SCHEMBL3914430 | 0.75 | MKNK1 (0.41) | PABPC1EIF4HCA1CA2CA9 | |
| SCHEMBL30752023 | 0.74 | CA1 (0.49) | PABPC1EIF4HCA12CA1CA2 | |
| SCHEMBL2575446 | 0.74 | CA1 (0.49) | PABPC1EIF4HCA12CA1CA2 | |
| SCHEMBL5668003 | 0.74 | NPC1 (0.57) | PABPC1EIF4HCA12CA1CA2 | |
| SCHEMBL7452418 | 0.73 | KDM4E (0.49) | SMN1; SMN2MAPTHTTTYK2JAK2 | |
| SCHEMBL2698248 | 0.73 | LMNA (0.65) | PABPC1EIF4HCA1CA2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115175908-B | Aryl or heteroaryl pyridone or pyrimidinone derivatives, and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2024-07-23 | — | — | CN | disclosed |
| US-20230118795-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | SUZHOU ZELGEN BIOPHARMACEUTICALS CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| EP-4092026-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2022-11-23 | — | — | EP | disclosed |
| CN-115175908-A | Aryl or heteroaryl pyridone or pyrimidone derivative and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| WO-2022135591-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDONE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-06-30 | — | — | WO | disclosed |
| CN-114671866-A | Aryl or heteroaryl pyridone or pyrimidone derivative and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-06-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230118795-A1 | ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | KRAS, NRAS, HRAS | PABPC1 2658/4885EIF4H 3250/4885CA12 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.