Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.81 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.54 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.52 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.52 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.52 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.52 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.52 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.52 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.52 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.52 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.52 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 9/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.81 |
| ▸ | TP53 | P04637 | 2/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL467100 | 1.00 | DRD4 (0.81) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL467099 | 1.00 | DRD4 (0.81) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| SCHEMBL10873714 | 0.90 | DRD2 (1.00) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| SCHEMBL11563888 | 0.82 | DRD2 (1.00) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| SCHEMBL14218592 | 0.77 | DRD2 (0.74) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| Clopipazan SCHEMBL11573662 | 0.77 | SETD7 (0.61) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| Clopipazan SCHEMBL11573664 | 0.77 | SETD7 (0.61) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| Metoxepin SCHEMBL2109740 | 0.74 | DRD2 (0.70) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| SCHEMBL11577989 | 0.72 | MAPT (0.56) | DRD4DRD2MAPTCYP1A2CYP3A4 | |
| SCHEMBL11577371 | 0.71 | DRD2 (0.67) | DRD4DRD2MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230122476-A1 | Lighting Device to Promote Circadian Health | CHILDREN'S HOSPITAL MEDICAL CENTER | 2023-04-20 | — | — | US | disclosed |
| EP-4103276-A2 | LIGHTING DEVICE TO PROMOTE CIRCADIAN HEALTH | Children's Hospital Medical Center (US) | 2022-12-21 | — | — | EP | disclosed |
| US-20220244263-A1 | METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-08-04 | — | — | US | disclosed |
| JP-2022069740-A | AUTOPHAGY INHIBITOR AND ANTICANCER DRUG | 国立大学法人九州大学 | 2022-05-12 | — | — | JP | disclosed |