Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26669264 | 0.84 | GAA (0.44) | KIF11MAPTKDM4EGAATNNI3K | |
| SCHEMBL26669262 | 0.81 | PTGS2 (0.47) | CA2CA1CA9CA12KIF11 | |
| SCHEMBL29704172 | 0.80 | PDE2A (0.40) | CA2CA1CA9KIF11PTGES2 | |
| SCHEMBL22718342 | 0.74 | KDM4E (0.54) | KIF11MAPTKDM4EGAATNNI3K | |
| SCHEMBL29704094 | 0.74 | KDM4E (0.54) | KIF11MAPTKDM4EGAATNNI3K | |
| SCHEMBL26669331 | 0.74 | CA1 (0.42) | CA2CA1DHODHCA9CA12 | |
| SCHEMBL20766320 | 0.70 | PTGES2 (0.65) | CA2CA1CA9CA12KIF11 | |
| SCHEMBL20766416 | 0.70 | CA2 (0.71) | CA2CA1CA9CA12KIF11 | |
| SCHEMBL30114184 | 0.69 | KDM4E (0.64) | CA2CA1CA9CA12KIF11 | |
| SCHEMBL26497636 | 0.68 | DHODH (0.51) | CA2CA1DHODHCA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022159986-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2022-07-28 | — | — | WO | disclosed |