Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SDCBP | O00560 | 1/20 | 0.41 |
| ▸ | SDC2 | P34741 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29096629 | 0.80 | CYP17A1 (0.49) | NAMPTHDAC1CHEK1AKT2 | |
| SCHEMBL3180689 | 0.78 | L3MBTL1 (0.61) | L3MBTL1NAMPTHDAC1MAPTTDP1 | |
| SCHEMBL5796279 | 0.75 | L3MBTL1 (0.56) | L3MBTL1NAMPTHDAC1LMNAMAPT | |
| SCHEMBL506891 | 0.75 | CYP17A1 (0.61) | L3MBTL1NAMPTHDAC1AKT1GAA | |
| SCHEMBL7290389 | 0.75 | NOTUM (0.54) | L3MBTL1KDM4ELMNACYP1A2 | |
| SCHEMBL2567630 | 0.74 | HDAC1 (0.57) | L3MBTL1NAMPTHDAC1MAPTTDP1 | |
| SCHEMBL1691047 | 0.74 | HDAC1 (0.67) | L3MBTL1NAMPTHDAC1LMNAGAA | |
| SCHEMBL15322811 | 0.74 | NAMPT (0.50) | L3MBTL1NAMPTHDAC1AKT1MAPT | |
| SCHEMBL24088159 | 0.74 | L3MBTL1 (0.50) | L3MBTL1NAMPTHDAC1AKT1KDM4E | |
| SCHEMBL22400217 | 0.74 | NAMPT (0.50) | L3MBTL1NAMPTHDAC1AKT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259144-A1 | SMARCA DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |