Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20520767 | 1.00 | LMNA (0.44) | LMNAOPRK1PDE4BGABRA1GABRB1 | |
| SCHEMBL28735724 | 0.87 | LMNA (0.41) | LMNAOPRK1MEN1KMT2AHSD17B10 | |
| SCHEMBL20522102 | 0.87 | PDE4B (0.39) | LMNAPDE4BMEN1KMT2AKDM4E | |
| SCHEMBL29705107 | 0.87 | PDE4B (0.39) | LMNAPDE4BMEN1KMT2AKDM4E | |
| SCHEMBL20520979 | 0.83 | LMNA (0.47) | LMNAOPRK1GABRA1GABRB1GABRA3 | |
| SCHEMBL23654328 | 0.80 | — | — | |
| SCHEMBL20520988 | 0.79 | LMNA (0.53) | LMNAOPRK1GABRA1GABRB1GABRA3 | |
| SCHEMBL29705153 | 0.79 | LMNA (0.53) | LMNAOPRK1GABRA1GABRB1GABRA3 | |
| SCHEMBL21815626 | 0.78 | LMNA (0.53) | LMNAOPRK1GABRA1GABRB1GABRA3 | |
| SCHEMBL3696586 | 0.77 | LMNA (0.64) | LMNAGABRA1GABRB1GABRA3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |