SCHEMBL29705308

SCHEMBL29705308

C[Si](C)(C)CCOCn1nc(C#N)c2cc(O)cnc21

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.33
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27215112 1.00 DGAT1 (0.33) DGAT1NPC1
SCHEMBL27215153 0.86 NPC1 (0.30) NPC1
SCHEMBL16537002 0.86 DGAT1 (0.36) DGAT1
SCHEMBL23042416 0.83 SPR (0.34) DGAT1NPC1
SCHEMBL29705192 0.83 SPR (0.34) DGAT1NPC1
SCHEMBL24566831 0.81 NPC1 (0.32) DGAT1NPC1
SCHEMBL27215304 0.79 DGAT1 (0.40) DGAT1NPC1
SCHEMBL16516690 0.79 NPC1 (0.35) DGAT1NPC1
SCHEMBL27215150 0.79 NPC1 (0.33) DGAT1NPC1
SCHEMBL27215183 0.79 KLKB1 (0.33) DGAT1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022159745-A1 GCN2 MODULATING COMPOUNDS AND USES THEREOF HIBERCELL, INC. (US) 2022-07-28 WO disclosed