SCHEMBL29707145

SCHEMBL29707145

Cc1cccc(NC(=N)c2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
RXFP1 Q9HBX9 2/20 0.57
KCNK3 O14649 2/20 0.57
KCNK9 Q9NPC2 2/20 0.57
POLB P06746 1/20 0.57
NPSR1 Q6W5P4 1/20 0.53
HSD17B10 Q99714 1/20 0.53
KCNH2 Q12809 1/20 0.53
MAPT P10636 5/20 0.52
CYP1A2 P05177 2/20 0.52
NPC1 O15118 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
ALOX12 P18054 1/20 0.52
CYP2C19 P33261 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
ALDH1A1 P00352 2/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
HTT P42858 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28448195 1.00 MEN1 (0.57) MEN1KMT2ARXFP1KCNK3KCNK9
SCHEMBL20053034 0.89 MEN1 (0.57) MEN1KMT2ARXFP1KCNK3KCNK9
SCHEMBL28294635 0.85 THRB (0.53) MEN1KMT2AKCNK3KCNK9POLB
SCHEMBL13302660 0.81 NPSR1 (0.57) MEN1KMT2ARXFP1KCNK3KCNK9
SCHEMBL23332259 0.81 NPC1 (0.52) MEN1KMT2AKCNK3KCNK9POLB
SCHEMBL393417 0.80 ALDH1A1 (0.48) MEN1KMT2AKCNK3KCNK9HSD17B10
SCHEMBL2154879 0.79 NPC1 (0.52) MEN1KMT2APOLBNPSR1HSD17B10
SCHEMBL4853047 0.79 NPC1 (0.61) MEN1KMT2ARXFP1POLBMAPT
SCHEMBL27776813 0.79 KCNK3 (0.55) MEN1KMT2ARXFP1KCNK3KCNK9
SCHEMBL6422898 0.79 HSD17B10 (0.62) MEN1KMT2ARXFP1KCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113264899-B 1,3,5-oxadiazine compound and preparation and application thereof 台州学院 2022-06-14 CN disclosed