Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28824305 | 1.00 | SLC22A12 (0.49) | SLC22A12XDHCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28824302 | 0.81 | CHRNB4 (0.48) | SLC22A12XDHCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28801068 | 0.78 | RAPGEF4 (0.44) | NPC1RAB9ASMN1; SMN2POLBHTT | |
| SCHEMBL30494419 | 0.77 | CHRNB4 (0.48) | SLC22A12XDHRAB9ACHRNB4CHRNA3 | |
| SCHEMBL26465213 | 0.77 | CHRNB4 (0.48) | SLC22A12XDHRAB9ACHRNB4CHRNA3 | |
| SCHEMBL4156639 | 0.77 | SCN9A (0.54) | SLC22A12XDHCHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL29707607 | 0.77 | SCN9A (0.54) | SLC22A12XDHCHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL4147660 | 0.77 | HSD17B10 (0.48) | SLC22A12XDHCYP3A4CHRNB4CHRNA3 | |
| SCHEMBL2821463 | 0.77 | RAB9A (0.57) | SLC22A12XDHNPC1RAB9ACHRNB4 | |
| SCHEMBL2392625 | 0.75 | TSHR (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805192-B | Tricyclic XOR/URAT1 dual inhibitor containing 2-hydroxybenzoic acid and preparation method and application thereof | 华南理工大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114805192-A | Tricyclic XOR/URAT1 dual inhibitor containing 2-hydroxybenzoic acid and preparation method and application thereof | 华南理工大学 | 2022-07-29 | — | — | CN | disclosed |