Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15607794 | 1.00 | HDAC1 (0.44) | HDAC1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL12650248 | 0.91 | LIPE (0.42) | HDAC1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL13893964 | 0.86 | MAPT (0.49) | LIPEMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL26109550 | 0.85 | POLB (0.50) | HDAC1HDAC3HDAC2LIPEMAPT | |
| SCHEMBL2992272 | 0.84 | LIPE (0.51) | LIPEMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL30586951 | 0.84 | MEN1 (0.51) | LIPEMAPTCASP3SMN1; SMN2 | |
| SCHEMBL124355 | 0.84 | MEN1 (0.51) | LIPEMAPTCASP3SMN1; SMN2 | |
| SCHEMBL29709477 | 0.83 | RAB9A (0.54) | LIPEMAPTBTKSMN1; SMN2NPC1 | |
| SCHEMBL104612 | 0.83 | RAB9A (0.54) | LIPEMAPTBTKSMN1; SMN2NPC1 | |
| SCHEMBL2995904 | 0.82 | F10 (0.56) | HDAC1HDAC3HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008328-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | AbbVie Inc. (US) | 2022-06-08 | — | — | EP | disclosed |