Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23165769 | 1.00 | ABL1 (0.39) | ABL1MAP4K1KDM5BBRD4ALDH1A1 | |
| SCHEMBL25254065 | 0.72 | BRPF1 (0.41) | BRD4ALDH1A1ARNPC1RAB9A | |
| SCHEMBL23165700 | 0.72 | ABL1 (0.36) | ABL1MAP4K1HRH3 | |
| SCHEMBL25077726 | 0.71 | TLR8 (0.42) | ABL1ALDH1A1NPC1RAB9A | |
| SCHEMBL29710178 | 0.71 | BRD4 (0.49) | BRD4ALDH1A1 | |
| SCHEMBL23166181 | 0.71 | BRD4 (0.49) | BRD4ALDH1A1 | |
| SCHEMBL3181211 | 0.71 | AR (0.69) | ARPGRNR3C2 | |
| SCHEMBL19533512 | 0.70 | PCSK9 (0.50) | BRD4ALDH1A1HRH3CA12CA9 | |
| SCHEMBL11012132 | 0.69 | AR (0.47) | ABL1ALDH1A1ARHRH3 | |
| SCHEMBL30104800 | 0.69 | F10 (0.43) | ALDH1A1CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4037683-A1 | SUBSTITUTED 1, 6-NAPHTHYRIDINE INHIBITORS OF CDK5 | Goldfinch Bio, Inc. (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-114761000-A | Substituted 1, 6-naphthyridine inhibitors of CDK5 | 金翅雀生物公司 | 2022-07-15 | — | — | CN | disclosed |