Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21501788 | 1.00 | GAA (0.42) | GAAKCNQ3KCNQ2MAPTKMT2A | |
| SCHEMBL21501789 | 0.84 | ALDH1A1 (0.42) | GAAKCNQ3KCNQ2MAPTKMT2A | |
| SCHEMBL21501801 | 0.84 | ARNT (0.39) | GAAKCNQ3KCNQ2MAPTNPC1 | |
| SCHEMBL29721721 | 0.84 | ARNT (0.39) | GAAKCNQ3KCNQ2MAPTNPC1 | |
| SCHEMBL29721786 | 0.84 | ALDH1A1 (0.42) | GAAKCNQ3KCNQ2MAPTKMT2A | |
| SCHEMBL20134036 | 0.83 | KCNQ2 (0.58) | GAAKCNQ3KCNQ2MAPTKMT2A | |
| SCHEMBL29721739 | 0.83 | KCNQ2 (0.58) | GAAKCNQ3KCNQ2MAPTKMT2A | |
| SCHEMBL29721814 | 0.82 | AURKA (0.46) | KCNQ3KCNQ2MAPTKMT2AMEN1 | |
| SCHEMBL20129863 | 0.82 | AURKA (0.46) | KCNQ3KCNQ2MAPTKMT2AMEN1 | |
| SCHEMBL21496383 | 0.82 | IDO1 (0.44) | GAAKCNQ3KCNQ2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | KCNH3, KCNH2, KCNJ11 | GAA 4792/4885KCNQ3 43/4885KCNQ2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.