Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLA1 | P09884 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26078475 | 0.84 | CYP3A4 (0.50) | CYP3A4MAPTTP53MEN1KMT2A | |
| SCHEMBL29552479 | 0.78 | CYP3A4 (0.56) | CYP3A4MAPTTP53MEN1KMT2A | |
| SCHEMBL28693741 | 0.76 | KARS1 (0.59) | CYP3A4MAPTTP53MEN1KMT2A | |
| SCHEMBL9359643 | 0.74 | CYP3A4 (0.53) | CYP3A4MAPTTP53MEN1KMT2A | |
| SCHEMBL9364236 | 0.74 | CYP3A4 (0.72) | CYP3A4MAPTTP53MEN1KMT2A | |
| Totaradiol SCHEMBL30445386 | 0.68 | CYP3A4 (0.70) | CYP3A4MAPTTP53MEN1KMT2A | |
| SCHEMBL28730781 | 0.67 | CYP3A4 (0.58) | CYP3A4MAPTTP53MEN1KMT2A | |
| Triptophenolide SCHEMBL29429178 | 0.65 | CYP3A4 (1.00) | CYP3A4MAPTTP53MEN1KMT2A | |
| Triptophenolide SCHEMBL19236270 | 0.65 | CYP3A4 (1.00) | CYP3A4MAPTTP53MEN1KMT2A | |
| SCHEMBL20366973 | 0.64 | KARS1 (0.61) | CYP3A4MAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114642171-B | Induction method of high-activity tripterygium wilfordii metabolic products and tripterygium wilfordii active metabolic composition | 华侨大学 | 2023-04-25 | — | — | CN | claimed |
| CN-114642171-A | Induction method of high-activity tripterygium wilfordii metabolite and tripterygium wilfordii active metabolic composition | 华侨大学 | 2022-06-21 | — | — | CN | claimed |
| CN-114642171-B | Induction method of high-activity tripterygium wilfordii metabolic products and tripterygium wilfordii active metabolic composition | 华侨大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-114642171-A | Induction method of high-activity tripterygium wilfordii metabolite and tripterygium wilfordii active metabolic composition | 华侨大学 | 2022-06-21 | — | — | CN | disclosed |