Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | USP2 | O75604 | 4/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 19-Hydroxytotarol SCHEMBL13423507 | 0.84 | CYP3A4 (1.00) | CYP3A4MAPTUSP2ALOX15HPGD | |
| 19-Hydroxytotarol SCHEMBL12998342 | 0.84 | CYP3A4 (1.00) | CYP3A4MAPTUSP2ALOX15HPGD | |
| SCHEMBL9359643 | 0.80 | CYP3A4 (0.53) | CYP3A4MAPTUSP2ALOX15HPGD | |
| SCHEMBL26078475 | 0.78 | CYP3A4 (0.50) | CYP3A4MAPTUSP2ALOX15HPGD | |
| 18-Hydroxyferruginol SCHEMBL18290210 | 0.77 | KARS1 (0.67) | CYP3A4MAPTUSP2ALOX15HPGD | |
| 18-Hydroxyferruginol SCHEMBL32666150 | 0.77 | KARS1 (0.67) | CYP3A4MAPTUSP2ALOX15HPGD | |
| SCHEMBL29552479 | 0.76 | CYP3A4 (0.56) | CYP3A4MAPTUSP2ALOX15HPGD | |
| Pomiferin A SCHEMBL4549111 | 0.75 | KARS1 (1.00) | CYP3A4MAPTALOX15KARS1MEN1 | |
| Pomiferin A SCHEMBL13039025 | 0.75 | KARS1 (1.00) | CYP3A4MAPTALOX15KARS1MEN1 | |
| Pomiferin A SCHEMBL2728630 | 0.75 | KARS1 (1.00) | CYP3A4MAPTALOX15KARS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472733-B1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| EP-0472733-A1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-04 | — | — | EP | disclosed |