Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552479 | 0.86 | CYP3A4 (0.56) | CYP3A4SMN1; SMN2ARMAPTUSP2 | |
| SCHEMBL9364236 | 0.80 | CYP3A4 (0.72) | CYP3A4SMN1; SMN2ARMAPTUSP2 | |
| SCHEMBL29552426 | 0.78 | USP2 (0.43) | CYP3A4SMN1; SMN2ARMAPTUSP2 | |
| SCHEMBL26078466 | 0.76 | KARS1 (0.65) | CYP3A4MAPTALOX15TP53MEN1 | |
| SCHEMBL26078475 | 0.76 | CYP3A4 (0.50) | CYP3A4SMN1; SMN2ARMAPTUSP2 | |
| SCHEMBL8855162 | 0.74 | CYP3A4 (0.57) | CYP3A4SMN1; SMN2MAPTUSP2HPGD | |
| SCHEMBL29725331 | 0.74 | CYP3A4 (0.49) | CYP3A4SMN1; SMN2ARMAPTUSP2 | |
| SCHEMBL29552651 | 0.74 | FDPS (0.37) | CYP3A4SMN1; SMN2MAPTUSP2HPGD | |
| SCHEMBL9359538 | 0.70 | KARS1 (0.34) | CYP3A4MAPTUSP2HPGDALOX15 | |
| SCHEMBL28730781 | 0.69 | CYP3A4 (0.58) | CYP3A4SMN1; SMN2ARMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472733-B1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5192817-A | Interleukin-1 inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0472733-A1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-04 | — | — | EP | disclosed |