Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.35 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.35 |
| ▸ | INMT | O95050 | 4/20 | 0.88 |
| ▸ | USP2 | O75604 | 2/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 3/20 | 0.32 |
| ▸ | NOS1 | P29475 | 3/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8469764 | 0.96 | INMT (0.95) | INMTUSP2ACHESIGMAR1SMN1; SMN2 | |
| Bromide SCHEMBL14761484 | 0.96 | INMT (0.95) | INMTUSP2ACHESIGMAR1SMN1; SMN2 | |
| Bromide SCHEMBL29980319 | 0.94 | INMT (0.91) | INMTUSP2ACHESIGMAR1SMN1; SMN2 | |
| SCHEMBL2734323 | 0.94 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2TDP1 | |
| SCHEMBL10601682 | 0.94 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2TDP1 | |
| SCHEMBL3047 | 0.94 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2TDP1 | |
| SCHEMBL17417853 | 0.94 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2TDP1 | |
| SCHEMBL16583523 | 0.94 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2TDP1 | |
| Bromide SCHEMBL18093523 | 0.92 | INMT (0.88) | INMTUSP2ACHESIGMAR1SMN1; SMN2 | |
| Iodide SCHEMBL23365018 | 0.91 | INMT (0.95) | INMTUSP2ACHESIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267591-A2 | ORGANOMETALLIC COMPOUNDS | Umicore AG & Co. KG (DE) | 2023-11-01 | — | — | EP | claimed |
| CN-116802187-A | Organometallic compounds | 优米科尔股份公司及两合公司 | 2023-09-22 | — | — | CN | claimed |
| WO-2022136049-A2 | ORGANOMETALLIC COMPOUNDS | UMICORE AG & CO. KG (DE) | 2022-06-30 | — | — | WO | claimed |
| CN-112930340-B | New synthetic method of piperazinyl-ethoxy-bromophenyl derivatives and their use in the production of compounds containing them | 法国施维雅药厂 | 2025-01-07 | — | — | CN | disclosed |
| CN-119053608-A | Novel compound, conjugated polymer, method for producing same, composition for film formation, organic thin film, and organic semiconductor element | 东曹株式会社 | 2024-11-29 | — | — | CN | disclosed |
| CN-116847837-A | Improved synthesis of CRAC channel inhibitors | 钙医学公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-116802187-A | Organometallic compounds | 优米科尔股份公司及两合公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-4243813-A1 | IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS | Calcimedica, Inc. (US) | 2023-09-20 | — | — | EP | disclosed |
| CN-116057032-A | Process for preparing and purifying environmentally compatible detergents | 武田药品工业株式会社 | 2023-05-02 | — | — | CN | disclosed |
| WO-2022101654-A1 | IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS | CALCIMEDICA, INC. (US) | 2022-05-19 | — | — | WO | disclosed |