Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22491548 | 1.00 | GPR119 (0.54) | GPR119NR1H2NR1H3TGFBR1STS | |
| SCHEMBL23211871 | 0.92 | GPR119 (0.51) | GPR119NR1H2NR1H3STS | |
| SCHEMBL30567986 | 0.92 | GPR119 (0.51) | GPR119NR1H2NR1H3STS | |
| SCHEMBL22491507 | 0.90 | GPR119 (0.53) | GPR119 | |
| SCHEMBL30149843 | 0.88 | GPR119 (0.49) | GPR119NR1H2NR1H3 | |
| SCHEMBL30568010 | 0.88 | GPR119 (0.49) | GPR119NR1H2NR1H3 | |
| SCHEMBL23212048 | 0.88 | GPR119 (0.49) | GPR119NR1H2NR1H3 | |
| SCHEMBL24621774 | 0.86 | KDM4E (0.53) | GPR119NR1H2 | |
| SCHEMBL22491504 | 0.85 | SETD7 (0.47) | — | |
| SCHEMBL1473494 | 0.81 | KDM4E (0.46) | GPR119STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11420961-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3717477-B1 | NEW HETEROCYCLIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2022-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11420961-B2 | Heterocyclic compounds | LPXN, MLX, CCNY | GPR119 3037/4885NR1H2 1894/4885NR1H3 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.