Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ro-24-7429. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRE | P78334 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8844868 | 0.83 | KMT2A (1.00) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL30289323 | 0.83 | KMT2A (1.00) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL29710678 | 0.81 | CHRM1 (0.67) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL9686097 | 0.81 | MEN1 (0.75) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL27486849 | 0.74 | MEN1 (0.63) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL464739 | 0.72 | MEN1 (0.60) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL15400202 | 0.71 | MEN1 (0.59) | MEN1KMT2AGABRA1GABRA5GABRA3 | |
| SCHEMBL9422490 | 0.70 | KMT2A (0.73) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL9686843 | 0.70 | MEN1 (0.55) | MEN1KMT2ACNR1NTSR1OPRK1 | |
| SCHEMBL12493436 | 0.70 | GABRA1 (0.68) | MEN1KMT2AOPRK1GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022138936-A1 | MYELIN SHEATH REPAIR AGENT | 国立研究開発法人国立精神・神経医療研究センター | 2022-06-30 | — | — | WO | disclosed |