Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7004500 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL906010 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL47867 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL1940651 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL1135949 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL5311584 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL6690080 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL9405454 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL372318 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL9364269 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020090738-A1 | System and method of microdispensing and arrays of biolayers provided by same | I-STAT CORPORATION | 2002-07-11 | — | — | US | claimed |
| EP-0442969-B1 | WHOLLY MICROFABRICATED BIOSENSORS AND PROCESS FOR THE MANUFACTURE AND USE THEREOF | I STAT CORP (US) | 2002-02-27 | — | — | EP | claimed |
| US-6306594-B1 | MICRODISPENSING AMOUNT OF PHOTOFORMABLE MATRIX ONTO SURFACE TO COVER PREDETERMINED AREA, DRYING MATRIX, ALIGNING WITH MASK, EXPOSING TO RADIATION, THEN DEVELOPING EXPOSED MATRIX TO REMOVE EXCESS; BIOSENSORS | I-STAT CORPORATION | 2001-10-23 | — | — | US | claimed |
| JP-3105919-B2 | — | — | 2000-11-06 | — | — | JP | claimed |
| US-5554339-A | Process for the manufacture of wholly microfabricated biosensors | I-STAT CORPORATION (US) | 1996-09-10 | — | — | US | claimed |
| US-5466575-A | Process for the manufacture of wholly microfabricated biosensors | I-STAT CORPORATION (US) | 1995-11-14 | — | — | US | claimed |
| EP-0442969-A4 | WHOLLY MICROFABRICATED BIOSENSORS AND PROCESS FOR THE MANUFACTURE AND USE THEREOF | — | 1993-05-12 | — | — | EP | claimed |
| US-5200051-A | Base sensor, permselective layer, biolayer of active molecule and support matrix | I-STAT CORPORATION (US) | 1993-04-06 | — | — | US | claimed |
| EP-0442969-A1 | WHOLLY MICROFABRICATED BIOSENSORS AND PROCESS FOR THE MANUFACTURE AND USE THEREOF | I-STAT CORPORATION (US) | 1991-08-28 | — | — | EP | claimed |
| WO-1990005910-A1 | WHOLLY MICROFABRICATED BIOSENSORS AND PROCESS FOR THE MANUFACTURE AND USE THEREOF | I STAT CORP (US) | 1990-05-31 | — | — | WO | claimed |
| WO-1990005910-A2 | WHOLLY MICROFABRICATED BIOSENSORS AND PROCESS FOR THE MANUFACTURE AND USE THEREOF | I-STAT CORPORATION (US) | 1990-05-31 | — | — | WO | claimed |
| US-4173453-A | Topical hair coloring formulation in the form of suspension, lotion and cream | CDC Research Inc. (US) | 1979-11-06 | — | — | US | claimed |
| US-7770534-B2 | Changed condition indicator | THERMOPROX | 2010-08-10 | — | — | US | disclosed |
| US-20070151502-A1 | Changed condition indicator | THERMOPROX | 2007-07-05 | — | — | US | disclosed |
| US-7074610-B2 | System and method of microdispensing and arrays of biolayers provided by same | I-STAT CORPORATION (US) | 2006-07-11 | — | — | US | disclosed |
| US-20020090738-A1 | System and method of microdispensing and arrays of biolayers provided by same | I-STAT CORPORATION | 2002-07-11 | — | — | US | disclosed |
| US-4173453-A | Topical hair coloring formulation in the form of suspension, lotion and cream | CDC Research Inc. (US) | 1979-11-06 | — | — | US | disclosed |
| US-4098922-A | METHOD FOR DEPOSITING A METAL ON A SURFACE | WESTERN ELECTRIC COMPANY, INC. (US) | 1978-07-04 | — | — | US | disclosed |
| US-4084023-A | Method for depositing a metal on a surface | WESTERN ELECTRIC COMPANY, INC. (US) | 1978-04-11 | — | — | US | disclosed |
| US-3930963-A | METHOD FOR THE PRODUCTION OF RADIANT ENERGY IMAGED PRINTED CIRCUIT BOARDS | PHOTOCIRCUITS DIVISION OF KOLLMORGEN CORPORATION (US) | 1976-01-06 | — | — | US | disclosed |