Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29731850 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL14924375 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL14925849 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL30512281 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL22802474 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL29741999 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL14924381 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL30578916 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL27965768 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL28855389 | 0.86 | GPR119 (0.48) | GPR119MAPTLMNAALDH1A1SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4050012-A1 | PYRIDONE BORONATES FOR THE PREPARATION OF INHIBITORS OF BTK ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2022-08-31 | — | — | EP | disclosed |
| EP-4019508-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2022-06-29 | — | — | EP | disclosed |