Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29731850 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL29741983 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL14924375 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL14925849 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL30512281 | 1.00 | GPR119 (0.50) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL29741999 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL14924381 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL30578916 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL27965768 | 0.87 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL28855389 | 0.86 | GPR119 (0.48) | GPR119MAPTLMNAALDH1A1SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752499-B1 | INHIBITORS OF TRPC6 | BOEHRINGER INGELHEIM INT (DE) | 2024-03-27 | — | — | EP | disclosed |
| CN-111770918-B | Inhibitors of TRPC6 | 勃林格殷格翰国际公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-115785097-A | BTK inhibitor and application thereof | 乳源东阳光药业有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-111333656-B | Process for preparing BTK inhibitors | 豪夫迈·罗氏有限公司 | 2023-03-14 | — | — | CN | disclosed |
| US-11485740-B2 | Inhibitors of TRPC6 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-11-01 | — | — | US | disclosed |
| US-20200399282-A1 | INHIBITORS OF TRPC6 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-12-24 | — | — | US | disclosed |
| CN-111770918-A | Inhibitors of TRPC6 | 勃林格殷格翰国际公司 | 2020-10-13 | — | — | CN | disclosed |
| CN-111303159-A | Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's Tyrosine Kinase (BTK) | 豪夫迈·罗氏有限公司 | 2020-06-19 | — | — | CN | disclosed |
| CN-106922146-B | Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's Tyrosine Kinase (BTK) | 豪夫迈·罗氏有限公司 | 2020-05-26 | — | — | CN | disclosed |
| CN-107011348-B | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | 霍夫曼-拉罗奇有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-104125959-A | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | HOFFMANN LA ROCHE | 2014-10-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399282-A1 | INHIBITORS OF TRPC6 | TRPC6, TRPC1, TRPC4 | GPR119 61/4885MAPT 1780/4885LMNA 724/4885 |
| US-11485740-B2 | Inhibitors of TRPC6 | TRPC6, TRPC1, TRPC4 | GPR119 61/4885MAPT 1780/4885LMNA 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.