Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14924381 | 1.00 | MAPT (0.47) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL29741999 | 1.00 | MAPT (0.47) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL19441886 | 0.91 | GPR119 (0.42) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL29731850 | 0.87 | GPR119 (0.50) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL29741983 | 0.87 | GPR119 (0.50) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL22802474 | 0.87 | GPR119 (0.50) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL14924375 | 0.87 | GPR119 (0.50) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL30512281 | 0.87 | GPR119 (0.50) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL14925849 | 0.87 | GPR119 (0.50) | MAPTALDH1A1LMNAGPR119MET | |
| SCHEMBL14914399 | 0.86 | CHRNB2 (0.47) | MAPTALDH1A1LMNARAB9ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107011348-B | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | 霍夫曼-拉罗奇有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-104203937-A | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity | HOFFMANN LA ROCHE | 2014-12-10 | — | — | CN | disclosed |
| CN-104125959-A | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | HOFFMANN LA ROCHE | 2014-10-29 | — | — | CN | disclosed |