Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.56 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15855147 | 0.89 | POLB (0.53) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL12045547 | 0.88 | PKM (0.74) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL2433512 | 0.87 | POLB (0.67) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL15855141 | 0.86 | POLB (0.60) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL15855144 | 0.86 | F10 (0.57) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL4858718 | 0.86 | KMT2A (0.67) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL5070165 | 0.85 | PKM (0.78) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL890692 | 0.85 | POLB (0.71) | RAB9ANPC1KMT2APOLBPKM | |
| SCHEMBL155078 | 0.84 | RAB9A (0.61) | RAB9ANPC1KMT2AMEN1RXFP1 | |
| SCHEMBL3152166 | 0.83 | POLB (0.58) | RAB9ANPC1KMT2APOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107778224-B | Preparation method of betrixaban intermediate | 鲁南制药集团股份有限公司 | 2020-06-26 | — | — | CN | claimed |
| EP-3293175-B1 | METHODS FOR PURIFICATION OF SERINE PROTEASES | ALEXION PHARMA INC (US) | 2021-12-01 | — | — | EP | disclosed |
| CN-107778224-B | Preparation method of betrixaban intermediate | 鲁南制药集团股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-107778224-B | Preparation method of betrixaban intermediate | 鲁南制药集团股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-107778223-B | Preparation method of betrixaban maleate | 鲁南制药集团股份有限公司 | 2020-05-15 | — | — | CN | disclosed |
| EP-2542529-B1 | URETHANES, UREAS, AMIDINES AND RELATED INHIBITORS OF FACTOR XA | LLC PHARMADIALL (RU) | 2019-09-04 | — | — | EP | disclosed |
| US-20190046510-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | MILLENNIUM PHARMACEUTICALS, INC. | 2019-02-14 | — | — | US | disclosed |
| US-20190046510-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | MILLENNIUM PHARMACEUTICALS, INC. | 2019-02-14 | — | — | US | disclosed |
| EP-3293175-A1 | METHODS FOR PURIFICATION OF SERINE PROTEASES | Portola Pharmaceuticals, Inc. (US) | 2018-03-14 | — | — | EP | disclosed |
| US-20170326119-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | MILLENNIUM PHARMACEUTICALS, INC. | 2017-11-16 | — | — | US | disclosed |
| US-20070112039-A1 | Better thermal and hydrolytic stability than the free-base compounds; N-(5-chloro-pyridin-2-yl)-2-(4-cyano-benzoyl-amino)-5-methoxy-benzamide Hydrochloride | MILLENNIUM PHARMACEUTICALS, INC. | 2007-05-17 | — | — | US | disclosed |
| US-20070112039-A1 | Better thermal and hydrolytic stability than the free-base compounds; N-(5-chloro-pyridin-2-yl)-2-(4-cyano-benzoyl-amino)-5-methoxy-benzamide Hydrochloride | MILLENNIUM PHARMACEUTICALS, INC. | 2007-05-17 | — | — | US | disclosed |
| US-7129245-B2 | Anticoagulants which act selectively on factor Xa; fast acting; oral; do not interfere with lysis of blood clots | ELI LILLY AND COMPANY (US) | 2006-10-31 | — | — | US | disclosed |
| US-20050282862-A1 | Aromatic amides | BEIGHT DOUGLAS W | 2005-12-22 | — | — | US | disclosed |
| EP-1140903-B1 | AROMATIC AMIDES | LILLY CO ELI (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6759414-B2 | ANTICOAGULANTS WHICH ACT SELECTIVELY ON FACTOR XA; FAST ACTING; ORAL; DO NOT INTERFERE WITH LYSIS OF BLOOD CLOTS | ELI LILLY AND COMPANY | 2004-07-06 | — | — | US | disclosed |
| US-20040029874-A1 | Aromatic amides | BEIGHT DOUGLAS WADE (US) | 2004-02-12 | — | — | US | disclosed |
| US-6635657-B1 | Pyridine derivatives; anticoagulants | ELI LILLY AND COMPANY | 2003-10-21 | — | — | US | disclosed |
| EP-1140903-A1 | AROMATIC AMIDES | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039118-A1 | AROMATIC AMIDES | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326119-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | F12, F11, TFPI | RAB9A 1402/4885NPC1 969/4885KMT2A 4431/4885 |
| US-20190046510-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | F12, F11, TFPI | RAB9A 1402/4885NPC1 969/4885KMT2A 4431/4885 |
| US-20040029874-A1 | Aromatic amides | F11, F12, F5 | RAB9A 2097/4885NPC1 1659/4885KMT2A 1697/4885 |
| US-20070112039-A1 | Better thermal and hydrolytic stability than the free-base compounds; N-(5-chloro-pyridin-2-yl)-2-(4-cyano-benzoyl-amino)-5-methoxy-benzamide Hydrochloride | F12, CMA1, F11 | RAB9A 2748/4885NPC1 2242/4885KMT2A 1327/4885 |
| US-20050282862-A1 | Aromatic amides | F11, F12, F5 | RAB9A 2097/4885NPC1 1659/4885KMT2A 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.