SCHEMBL29746483

SCHEMBL29746483

Nc1sccc1C(=O)NCc1ccc(Cl)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.47
HDAC1 Q13547 2/20 0.45
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
FPR2 P25090 1/20 0.42
CYP2C9 P11712 1/20 0.41
NAMPT P43490 1/20 0.41
FAAH O00519 1/20 0.41
KDM4E B2RXH2 3/20 0.40
MAPT P10636 2/20 0.40
GAA P10253 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
RAB9A P51151 1/20 0.40
ALDH1A1 P00352 4/20 0.40
MAPK1 P28482 1/20 0.40
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26606587 1.00 L3MBTL1 (0.47) L3MBTL1HDAC1MEN1KMT2AFPR2
SCHEMBL29746626 0.95 L3MBTL1 (0.46) L3MBTL1HDAC1MEN1KMT2AFPR2
SCHEMBL27929346 0.77 HDAC1 (0.55) L3MBTL1HDAC1MEN1KMT2AFPR2
SCHEMBL9765938 0.75 APEX1 (0.68) L3MBTL1HDAC1MEN1KMT2ACYP2C9
SCHEMBL625919 0.74 CYP2C9 (0.61) L3MBTL1HDAC1FPR2CYP2C9NAMPT
SCHEMBL22972337 0.74 MAPK1 (0.60) L3MBTL1HDAC1MEN1KMT2ACYP2C9
SCHEMBL13450245 0.74 L3MBTL1 (0.67) L3MBTL1HDAC1MEN1KMT2ARAB9A
SCHEMBL24570157 0.73 ALDH1A1 (0.58) L3MBTL1MEN1KMT2AKDM4EMAPT
SCHEMBL3704245 0.73 L3MBTL1 (0.56) L3MBTL1HDAC1FPR2CYP2C9NAMPT
SCHEMBL8837372 0.72 L3MBTL1 (0.74) L3MBTL1HDAC1CYP2C9NAMPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116583286-A Tetrahydrothienopyrimidine sulfonamide compounds 某久拉斯株式会社 2023-08-11 CN disclosed
WO-2022138812-A1 TETRAHYDRO THIENOPYRIDINE SULFONAMIDE COMPOUND モジュラス株式会社 2022-06-30 WO disclosed