Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28036275 | 1.00 | L3MBTL1 (0.53) | L3MBTL1TDP1KDM4EALDH1A1ATR | |
| SCHEMBL11931402 | 0.94 | L3MBTL1 (0.49) | L3MBTL1TDP1KDM4EALDH1A1ATR | |
| SCHEMBL30441012 | 0.92 | KDM4E (0.46) | L3MBTL1TDP1KDM4EALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL28013995 | 0.90 | KDM4E (0.44) | L3MBTL1TDP1KDM4EALDH1A1LMNA | |
| Tert-Butanol SCHEMBL25377982 | 0.89 | KDM4E (0.43) | L3MBTL1TDP1KDM4EALDH1A1LMNA | |
| SCHEMBL29416324 | 0.87 | L3MBTL1 (0.62) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL69990 | 0.87 | L3MBTL1 (0.62) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL16515769 | 0.86 | KDM4E (0.61) | L3MBTL1TDP1KDM4EALDH1A1LMNA | |
| SCHEMBL30665208 | 0.84 | ALDH1A1 (0.42) | L3MBTL1KDM4EALDH1A1ALOX15CYP3A4 | |
| SCHEMBL30665207 | 0.84 | ALDH1A1 (0.42) | L3MBTL1KDM4EALDH1A1ALOX15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112739697-B | Dimethylaminoazetidine amides as JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-112703037-B | 5-to 7-membered heterocyclic amides as JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-115190878-A | Crystalline hydrates of JAK inhibitor compounds | 施万生物制药研发IP有限责任公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110461839-B | JAK inhibitors containing 4-membered heterocyclic amides | 施万生物制药研发IP有限责任公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-110382498-B | Fused imidazole-piperidine JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-12 | — | — | CN | disclosed |