Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | AGER | Q15109 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24579118 | 1.00 | TGFBR1 (0.34) | TGFBR1NAPRTALOX5APFEN1KDM4E | |
| SCHEMBL24577485 | 0.87 | TGFBR1 (0.42) | TGFBR1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL29759692 | 0.87 | TGFBR1 (0.42) | TGFBR1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL29760051 | 0.85 | DHODH (0.42) | TGFBR1KDM4ETDP1ALDH1A1NPSR1 | |
| SCHEMBL24577988 | 0.81 | FFAR4 (0.36) | TGFBR1ALDH1A1TSHRL3MBTL1FFAR4 | |
| SCHEMBL30809497 | 0.77 | TGFBR1 (0.32) | TGFBR1FFAR4IRAK4 | |
| SCHEMBL29759601 | 0.76 | ALOX5AP (0.33) | ALOX5APFEN1 | |
| SCHEMBL24576864 | 0.76 | HDAC6 (0.41) | IRAK4 | |
| SCHEMBL30566471 | 0.76 | TYK2 (0.45) | TGFBR1IRAK4 | |
| SCHEMBL29759623 | 0.75 | HDAC6 (0.41) | TGFBR1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |