Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 12/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577035 | 1.00 | WNT1 (0.34) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL24576943 | 0.97 | SIGMAR1 (0.36) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29759593 | 0.97 | SIGMAR1 (0.36) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29759637 | 0.95 | WNT1 (0.39) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL24577897 | 0.95 | WNT1 (0.39) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29759639 | 0.93 | CHRM1 (0.36) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29759697 | 0.92 | CHRM1 (0.35) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL27185330 | 0.89 | PDCD1 (0.33) | CHRM1PDGFRAHRH3OGAIRAK4 | |
| SCHEMBL29760042 | 0.89 | PDCD1 (0.33) | CHRM1PDGFRAHRH3OGAIRAK4 | |
| SCHEMBL29759961 | 0.89 | IRAK4 (0.34) | WNT1GSK3BDYRK1ACHRM1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |