Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185330 | 1.00 | PDCD1 (0.33) | PDCD1CD274IRAK4PDGFRACHRM1 | |
| SCHEMBL27184975 | 0.93 | IRAK4 (0.34) | IRAK4PDGFRACHRM1HRH3TSHR | |
| SCHEMBL29759961 | 0.93 | IRAK4 (0.34) | IRAK4PDGFRACHRM1HRH3TSHR | |
| SCHEMBL24577265 | 0.91 | WNT1 (0.37) | IRAK4PDGFRACHRM1HRH3OGA | |
| SCHEMBL29759648 | 0.91 | WNT1 (0.37) | IRAK4PDGFRACHRM1HRH3OGA | |
| SCHEMBL24577035 | 0.89 | WNT1 (0.34) | IRAK4PDGFRACHRM1HRH3OGA | |
| SCHEMBL29759703 | 0.89 | WNT1 (0.34) | IRAK4PDGFRACHRM1HRH3OGA | |
| SCHEMBL29759593 | 0.88 | SIGMAR1 (0.36) | PDGFRACHRM1HRH3OGA | |
| SCHEMBL24576943 | 0.88 | SIGMAR1 (0.36) | PDGFRACHRM1HRH3OGA | |
| SCHEMBL24577378 | 0.88 | PDCD1 (0.35) | PDCD1CD274IRAK4PDGFRACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |