Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809555 | 0.85 | MAPT (0.43) | TGFBR1 | |
| SCHEMBL30566591 | 0.77 | KDM4E (0.43) | TGFBR1JAK3TGFBR2JAK2PARP1 | |
| SCHEMBL30566572 | 0.75 | MKNK1 (0.39) | TGFBR1JAK1JAK3JAK2TYK2 | |
| SCHEMBL30566447 | 0.75 | JAK2 (0.32) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29759623 | 0.74 | HDAC6 (0.41) | TGFBR1JAK3JAK2TYK2BTK | |
| SCHEMBL30809497 | 0.74 | TGFBR1 (0.32) | TGFBR1 | |
| SCHEMBL29760263 | 0.73 | CDC7 (0.43) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29759647 | 0.72 | CYP2E1 (0.34) | TGFBR1JAK1JAK3JAK2TYK2 | |
| SCHEMBL24578259 | 0.72 | KDR (0.39) | TGFBR1JAK1JAK3JAK2TYK2 | |
| SCHEMBL29759991 | 0.71 | MKNK1 (0.46) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |