Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809477 | 0.87 | HPGD (0.41) | TGFBR1NPC1 | |
| SCHEMBL30809480 | 0.87 | HPGD (0.41) | TGFBR1NPC1 | |
| SCHEMBL24579118 | 0.77 | TGFBR1 (0.34) | TGFBR1FFAR4IRAK4 | |
| SCHEMBL30566541 | 0.77 | TGFBR1 (0.34) | TGFBR1FFAR4IRAK4 | |
| SCHEMBL29760144 | 0.74 | TGFBR1 (0.43) | TGFBR1 | |
| SCHEMBL30809555 | 0.73 | MAPT (0.43) | TGFBR1NPC1 | |
| SCHEMBL24579116 | 0.71 | — | — | |
| SCHEMBL30809544 | 0.68 | MAPT (0.44) | TGFBR1NPC1 | |
| SCHEMBL30690824 | 0.68 | MAPT (0.34) | — | |
| SCHEMBL24577867 | 0.67 | KDM4E (0.31) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |