Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809544 | 0.87 | MAPT (0.44) | MAPTHPGDALDH1A1KDM4ETGFBR1 | |
| SCHEMBL30809480 | 0.87 | HPGD (0.41) | MAPTHPGDALDH1A1KDM4ETGFBR1 | |
| SCHEMBL30809477 | 0.87 | HPGD (0.41) | MAPTHPGDALDH1A1KDM4ETGFBR1 | |
| SCHEMBL29760144 | 0.85 | TGFBR1 (0.43) | TGFBR1 | |
| SCHEMBL29759559 | 0.76 | TGFBR1 (0.42) | MAPTHPGDALDH1A1KDM4ETGFBR1 | |
| SCHEMBL24577809 | 0.74 | TGFBR1 (0.43) | MAPTHPGDALDH1A1KDM4ETGFBR1 | |
| SCHEMBL24577381 | 0.73 | ALDH1A1 (0.40) | MAPTHPGDALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL30809497 | 0.73 | TGFBR1 (0.32) | TGFBR1NPC1 | |
| Hydrochloric Acid SCHEMBL29759531 | 0.73 | TGFBR1 (0.42) | MAPTHPGDALDH1A1KDM4ETGFBR1 | |
| Hydrochloric Acid SCHEMBL30566615 | 0.73 | TGFBR1 (0.42) | MAPTHPGDALDH1A1KDM4ETGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |