Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 9/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.33 |
| ▸ | LPL | P06858 | 3/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29108916 | 1.00 | LIPE (0.44) | LIPECXCR2P2RY1LPLLIPG | |
| SCHEMBL20428078 | 0.85 | LIPE (0.36) | LIPEP2RY1LPLLIPGROCK2 | |
| SCHEMBL25300352 | 0.84 | LIPE (0.42) | LIPE | |
| SCHEMBL29879749 | 0.84 | LIPE (0.42) | LIPE | |
| SCHEMBL20428063 | 0.84 | LIPE (0.35) | LIPELPLLIPGROCK2 | |
| SCHEMBL22293781 | 0.83 | LIPE (0.39) | LIPEP2RY1ROCK2 | |
| SCHEMBL1484864 | 0.83 | APLNR (0.38) | LIPELPLLIPGROCK2 | |
| SCHEMBL30292561 | 0.83 | APLNR (0.38) | LIPELPLLIPGROCK2 | |
| SCHEMBL25426624 | 0.82 | LIPE (0.55) | LIPE | |
| SCHEMBL23935943 | 0.82 | LIPE (0.36) | LIPEROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308566-A1 | PURINE DERIVATIVES AS ANTICANCER AGENTS | Tango Therapeutics, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022197892-A1 | PURINE DERIVATIVES AS ANTICANCER AGENTS | TANGO THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |