Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 5/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2981724 | 0.86 | CDK5 (0.44) | CDK5CDK5R1CCNA2CDK2HTR2C | |
| SCHEMBL4036579 | 0.85 | CDK5 (0.38) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL2972887 | 0.85 | CYP11B2 (0.41) | CDK5CDK5R1CCNA2CDK2HTR2C | |
| SCHEMBL2978113 | 0.85 | CDK5 (0.36) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL3391196 | 0.84 | HTR2A (0.36) | HTR2CHTR2BLMNAHTR2APOLB | |
| SCHEMBL13888934 | 0.81 | TNF (0.37) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL27984643 | 0.80 | HTR2C (0.44) | CDK5CDK5R1CCNA2CDK2HTR2C | |
| SCHEMBL13888932 | 0.79 | NPC1 (0.36) | IGF1RAXLMAPT | |
| SCHEMBL2981102 | 0.77 | CDK5 (0.43) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL2985558 | 0.77 | CDK5 (0.43) | CDK5CDK5R1CCNA2CDK2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286175-A1 | 2-(Pyridin-2-yl)-pyrimidines and Their Use for Controlling Harmful Fungi | GRAMMENOS WASSILIOS | 2010-11-11 | — | — | US | disclosed |
| US-7786043-B2 | 2-(pyridin-2-yl)-pyrimidines and their use for controlling harmful fungi | BASF AKTIENGESELLSCHAFT (DE) | 2010-08-31 | — | — | US | disclosed |
| EP-2172467-A1 | 2-(pyridin -2-yl)-pyrimidines and their use for controlling pathogenic fungi | BASF SE (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-2172466-A1 | 2-(pyridin-2-yl)-pyrimidines and use of same to combat hazardous fungi | BASF SE (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-2172465-A1 | 2-(pyridin -2-yl)-pyrimidines and their use for controlling pathogenic fungi | BASF SE (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-1773806-B1 | 2-(PYRIDIN-2-YL)-PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI | BASF SE (DE) | 2010-02-24 | — | — | EP | disclosed |
| US-20080027085-A1 | 2-(Pyridin-2-Yl)-Pyrimidines and Their Use for Controlling Harmful Fungi | BASF AKTIENGESELLSCHAFT (DE) | 2008-01-31 | — | — | US | disclosed |
| EP-1773806-A1 | 2-(PYRIDIN-2-YL)-PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI | BASF AKTIENGESELLSCHAFT (DE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010570-A1 | 2-(PYRIDIN-2-YL)-PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI | BASF AKTIENGESELLSCHAFT (DE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027085-A1 | 2-(Pyridin-2-Yl)-Pyrimidines and Their Use for Controlling Harmful Fungi | CBR1, CBR3, CNPY2 | CDK5 3167/4885CDK5R1 1389/4885CCNA2 167/4885 |
| US-20100286175-A1 | 2-(Pyridin-2-yl)-pyrimidines and Their Use for Controlling Harmful Fungi | CBR1, CBR3, CNPY2 | CDK5 3058/4885CDK5R1 1539/4885CCNA2 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.