Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977002 | 0.80 | CDK5 (0.38) | HTR2CHTR2BKMT2ACDK5CDK5R1 | |
| SCHEMBL11183504 | 0.76 | MAOA (0.41) | HTR2CTNKS2HDAC9GRM5MAOB | |
| SCHEMBL19674746 | 0.76 | MAPT (0.43) | — | |
| SCHEMBL22322760 | 0.75 | HTR2C (0.43) | HTR2CTNKS2CDK5CDK5R1CCNA2 | |
| SCHEMBL9959918 | 0.73 | CDK5 (0.74) | KMT2ACDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL11176219 | 0.73 | TNKS2 (0.36) | HTR2CTNKS2HTR2BHDAC9GRM5 | |
| SCHEMBL27999602 | 0.72 | MAPK1 (0.45) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL3869454 | 0.72 | KMT2A (0.41) | HTR2CKMT2AGRM5HDAC1HDAC2 | |
| SCHEMBL716608 | 0.72 | KMT2A (0.52) | HTR2CHTR2BKMT2AGRM5NPC1 | |
| SCHEMBL11188997 | 0.71 | HDAC9 (0.37) | HTR2CTNKS2HTR2BHDAC9GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103328451-B | Compounds for the reduction of beta-amyloid production | BRISTOL MYERS SQUIBB CO | 2015-06-10 | — | — | CN | disclosed |
| CN-102548557-B | Compounds for reducing beta-amyloid production | BRISTOL MYERS SQUIBB CO | 2014-12-24 | — | — | CN | disclosed |