Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205991 | 0.85 | MEN1 (0.69) | MEN1KMT2AGRM5RAB9ASMN1; SMN2 | |
| SCHEMBL30242551 | 0.85 | MEN1 (0.69) | MEN1KMT2AGRM5RAB9ASMN1; SMN2 | |
| SCHEMBL30242496 | 0.79 | MEN1 (0.49) | MEN1KMT2AGRM5AOC3SMN1; SMN2 | |
| SCHEMBL28929559 | 0.79 | MEN1 (0.49) | MEN1KMT2AGRM5AOC3SMN1; SMN2 | |
| SCHEMBL27156530 | 0.78 | MEN1 (0.50) | MEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL24869491 | 0.78 | MAOA (0.49) | RAB9ASMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL29771864 | 0.78 | MAOA (0.49) | RAB9ASMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL20214438 | 0.78 | KMT2A (0.58) | MEN1KMT2ARAB9ASMN1; SMN2GAA | |
| SCHEMBL29771862 | 0.77 | KMT2A (0.49) | MEN1KMT2AGRM5AOC3MAPT | |
| SCHEMBL25947319 | 0.73 | MEN1 (0.46) | MEN1KMT2AGRM5AOC3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4274829-A1 | THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2023-11-15 | — | — | EP | disclosed |
| CN-116981664-A | Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of NUAK kinase, compositions and uses thereof | 安大略省癌症研究所(OICR) | 2023-10-31 | — | — | CN | disclosed |
| WO-2022147620-A1 | THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |