Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27156530 | 0.84 | MEN1 (0.50) | KMT2AMEN1GRM5HTR2AHTR2C | |
| SCHEMBL30242496 | 0.83 | MEN1 (0.49) | KMT2AMEN1GRM5HTR2AHTR2C | |
| SCHEMBL28929559 | 0.83 | MEN1 (0.49) | KMT2AMEN1GRM5HTR2AHTR2C | |
| SCHEMBL25947319 | 0.82 | MEN1 (0.46) | KMT2AMEN1GRM5HTR2AHTR2C | |
| SCHEMBL16002405 | 0.81 | MEN1 (0.60) | KMT2AMEN1GRM5AOC3 | |
| SCHEMBL2205991 | 0.81 | MEN1 (0.69) | KMT2AMEN1SIRT6GRM5MAPT | |
| SCHEMBL30242551 | 0.81 | MEN1 (0.69) | KMT2AMEN1SIRT6GRM5MAPT | |
| SCHEMBL29771861 | 0.77 | MEN1 (0.52) | KMT2AMEN1SIRT6GRM5MAPT | |
| SCHEMBL22864645 | 0.74 | SIRT6 (0.50) | SIRT6MAPK1HTR2AHTR2CHTR2B | |
| SCHEMBL15727806 | 0.74 | HTR1A (0.50) | KMT2AMEN1HTR2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4274829-A1 | THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2023-11-15 | — | — | EP | disclosed |
| CN-116981664-A | Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of NUAK kinase, compositions and uses thereof | 安大略省癌症研究所(OICR) | 2023-10-31 | — | — | CN | disclosed |
| WO-2022147620-A1 | THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |