SCHEMBL29772014

SCHEMBL29772014

CN1CCCC(COc2cccc(Br)c2Cl)C1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.45
ROCK2 O75116 1/20 0.41
ROCK1 Q13464 1/20 0.41
CDC42BPB Q9Y5S2 1/20 0.41
CHRNB4 P30926 2/20 0.41
CHRNA3 P32297 2/20 0.41
EGFR P00533 3/20 0.40
FGFR1 P11362 3/20 0.40
FLT1 P17948 3/20 0.40
FLT4 P35916 3/20 0.40
KDR P35968 3/20 0.40
MAOA P21397 2/20 0.40
MAOB P27338 2/20 0.40
GUCY1B2 O75343 1/20 0.40
GUCY1A2 P33402 1/20 0.40
GUCY1A1 Q02108 1/20 0.40
GUCY1B1 Q02153 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
FAAH O00519 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23178053 1.00 HRH3 (0.45) HRH3ROCK2ROCK1CDC42BPBCHRNB4
SCHEMBL23167244 1.00 HRH3 (0.45) HRH3ROCK2ROCK1CDC42BPBCHRNB4
SCHEMBL19897839 0.86 MAOA (0.46) HRH3ROCK2ROCK1CDC42BPBCHRNB4
SCHEMBL30395486 0.86 MAOA (0.46) HRH3ROCK2ROCK1CDC42BPBCHRNB4
SCHEMBL14577983 0.78 CHRNB4 (0.54) HRH3ROCK2ROCK1CDC42BPBCHRNB4
SCHEMBL23178008 0.77 HRH3 (0.39) HRH3ROCK2ROCK1CDC42BPBCHRNB4
SCHEMBL29772002 0.77 CHRNB4 (0.56) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL18729042 0.77 RBP4 (0.47)
SCHEMBL18729041 0.77 RBP4 (0.47)
Hydrochloric Acid SCHEMBL7953408 0.76 HRH3 (0.50) HRH3CHRNB4CHRNA3EGFRMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4037776-A1 COMPOUNDS USEFUL AS IMMUNOMODULATORS Bristol-Myers Squibb Company (US) 2022-08-10 EP disclosed
CN-114761085-A Compounds useful as immunomodulators 百时美施贵宝公司 2022-07-15 CN disclosed