Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21261309 | 1.00 | DRD4 (0.49) | DRD4GRM2AKR1C3GRM5KMT2A | |
| SCHEMBL23536030 | 0.81 | GRM2 (0.43) | GRM2AKR1C3KMT2A | |
| SCHEMBL4960474 | 0.80 | KDM4E (0.52) | DRD4AKR1C3SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL21261239 | 0.79 | POLB (0.54) | DRD4GRM2GRM5KMT2AL3MBTL1 | |
| SCHEMBL21261308 | 0.79 | TSHR (0.45) | DRD4GRM2GRM5KMT2AL3MBTL1 | |
| SCHEMBL29772857 | 0.79 | TSHR (0.45) | DRD4GRM2GRM5KMT2AL3MBTL1 | |
| SCHEMBL30233081 | 0.78 | HPGD (0.53) | DRD4GRM2AKR1C3L3MBTL1MAPT | |
| SCHEMBL21261310 | 0.78 | MAPT (0.47) | DRD4GRM2KMT2AL3MBTL1MEN1 | |
| SCHEMBL23535932 | 0.77 | ENPP2 (0.53) | DRD4GRM2GRM5KMT2AL3MBTL1 | |
| SCHEMBL21261350 | 0.76 | SMN1; SMN2 (0.49) | DRD4GRM2GRM5KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150461-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. (US) | 2022-07-14 | — | — | WO | disclosed |