SCHEMBL4960474

SCHEMBL4960474

OCc1ccccc1N1CCN(c2ccccc2CO)CC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
PLA2G1B P04054 1/20 0.52
RAB9A P51151 1/20 0.52
ATG4B Q9Y4P1 1/20 0.52
NCF1 P14598 1/20 0.47
HTR7 P34969 3/20 0.46
DRD2 P14416 4/20 0.44
DRD3 P35462 4/20 0.44
DRD4 P21917 3/20 0.44
HTR1A P08908 2/20 0.44
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
HRH1 P35367 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
AKR1C3 P42330 1/20 0.42
APOBEC3G Q9HC16 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL721985 0.91 NCF1 (0.49) KDM4EALDH1A1PLA2G1BRAB9AATG4B
SCHEMBL12368809 0.90 NCF1 (0.61) KDM4EALDH1A1PLA2G1BRAB9AATG4B
SCHEMBL12416584 0.90 KDM4E (0.45) KDM4EALDH1A1PLA2G1BRAB9AATG4B
SCHEMBL2346705 0.90 KEAP1 (0.52) KDM4EALDH1A1PLA2G1BRAB9AATG4B
Hydrochloric Acid SCHEMBL10710768 0.90 NCF1 (0.47) KDM4EALDH1A1PLA2G1BRAB9AATG4B
Hydrochloric Acid SCHEMBL10711290 0.89 NCF1 (0.59) KDM4EALDH1A1PLA2G1BRAB9AATG4B
SCHEMBL2384862 0.86 ADRB1 (0.61) KDM4EALDH1A1NCF1HTR7DRD2
SCHEMBL1715455 0.86 AKR1C3 (0.50) KDM4EALDH1A1RAB9ANCF1AKR1C3
SCHEMBL2454168 0.84 DRD4 (0.63) KDM4EALDH1A1PLA2G1BRAB9AATG4B
SCHEMBL21261309 0.80 DRD4 (0.49) ALDH1A1DRD4SLC6A2SLC6A3AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1988108-B1 Temperature and pH-sensitive block copolymer having having excellent gel strength, method of preparing the same, and drug delivery system using the same UNIV SUNGKYUNKWAN FOUND (KR) 2014-09-10 EP claimed
US-20080274190-A1 TEMPERATURE AND pH - SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT GEL STRENGTH, METHOD OF PREPARING THE SAME, AND DRUG DELIVERY SYSTEM USING THE SAME SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) 2008-11-06 US claimed
EP-1988108-A1 Temperature and pH-sensitive block copolymer having having excellent gel strength, method of preparing the same, and drug delivery system using the same Sungkyunkwan University Foundation for Corporate Collaboration (KR) 2008-11-05 EP claimed
EP-1988108-B1 Temperature and pH-sensitive block copolymer having having excellent gel strength, method of preparing the same, and drug delivery system using the same UNIV SUNGKYUNKWAN FOUND (KR) 2014-09-10 EP disclosed
US-8586087-B2 Temperature and pH-sensitive block copolymer having excellent gel strength SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) 2013-11-19 US disclosed
US-20080274190-A1 TEMPERATURE AND pH - SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT GEL STRENGTH, METHOD OF PREPARING THE SAME, AND DRUG DELIVERY SYSTEM USING THE SAME SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) 2008-11-06 US disclosed
EP-1988108-A1 Temperature and pH-sensitive block copolymer having having excellent gel strength, method of preparing the same, and drug delivery system using the same Sungkyunkwan University Foundation for Corporate Collaboration (KR) 2008-11-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080274190-A1 TEMPERATURE AND pH - SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT GEL STRENGTH, METHOD OF PREPARING THE SAME, AND DRUG DELIVERY SYSTEM USING THE SAME TBCA, HSPA1B, AHSA1 KDM4E 4485/4885ALDH1A1 763/4885PLA2G1B 608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.