Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742873 | 0.90 | MEN1 (0.56) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL10786547 | 0.88 | CSNK2A1 (0.58) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL8712689 | 0.85 | CSNK2A1 (0.55) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL11213739 | 0.82 | CSNK2A1 (0.60) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL9768518 | 0.82 | HTT (0.58) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL9117698 | 0.82 | RAB9A (0.52) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL8085885 | 0.82 | HTT (0.58) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL10596742 | 0.82 | HTT (0.58) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL27944650 | 0.82 | HTT (0.58) | MEN1KMT2ARAB9AKDM4ELMNA | |
| SCHEMBL27954307 | 0.82 | HTT (0.58) | MEN1KMT2ARAB9AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4274828-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Global Enterprises Ltd. (BM) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150174-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Global Enterprises Ltd. (BM) | 2022-07-14 | — | — | WO | disclosed |