Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | CTH | P32929 | 3/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.39 |
| ▸ | RRM2 | P31350 | 2/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.34 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.34 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29773623 | 1.00 | NCOA3 (0.48) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773615 | 0.84 | NCOA3 (0.49) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773644 | 0.84 | NCOA3 (0.68) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL29773611 | 0.83 | NCOA3 (0.70) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773626 | 0.83 | NCOA3 (0.70) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773612 | 0.77 | NCOA3 (0.42) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773624 | 0.77 | NCOA3 (0.42) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773619 | 0.73 | TOP2A (0.48) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL29773614 | 0.73 | TOP2A (0.48) | NCOA3TOP2ACTHNCOA1RRM2 | |
| SCHEMBL17067848 | 0.69 | TOP2A (0.43) | TOP2AMAOBGLAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528774-B2 | Thiosemicarbazone compounds and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-01-20 | — | — | US | disclosed |
| US-20220274929-A1 | THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274929-A1 | THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF | TST, TPMT, ABCG2 | NCOA3 408/4885TOP2A 183/4885CTH 58/4885 |
| US-12528774-B2 | Thiosemicarbazone compounds and uses thereof | SCN2B, SCN1B, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | NCOA3 412/4885TOP2A 266/4885CTH 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.