Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638762 | 0.88 | ALDH1A1 (0.43) | ALDH1A1KDM4ESMN1; SMN2PDGFRBFGFR1 | |
| SCHEMBL3583697 | 0.85 | VCAM1 (0.48) | ALDH1A1KDM4ESMN1; SMN2PDGFRBFGFR1 | |
| SCHEMBL2966761 | 0.83 | VCAM1 (0.43) | ALDH1A1KDM4ESMN1; SMN2PDGFRBFGFR1 | |
| SCHEMBL3421496 | 0.76 | MAPT (0.46) | ALDH1A1KDM4ESMN1; SMN2HCAR3TDP1 | |
| SCHEMBL3421607 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2HCAR3TDP1 | |
| SCHEMBL3424399 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2HCAR3TDP1 | |
| SCHEMBL13037508 | 0.76 | PDGFRB (0.48) | ALDH1A1KDM4ESMN1; SMN2PDGFRBFGFR1 | |
| SCHEMBL13680345 | 0.75 | TDP1 (0.53) | ALDH1A1KDM4ESMN1; SMN2PDGFRBFGFR1 | |
| SCHEMBL12604704 | 0.75 | PDGFRB (0.56) | ALDH1A1KDM4ESMN1; SMN2PDGFRBFGFR1 | |
| SCHEMBL3585341 | 0.74 | VCAM1 (0.47) | PDGFRBFGFR1PDGFRAFLT1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776924-B2 | Nitroaniline-based alkylating agents and their use as prodrugs | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-08-17 | — | — | US | disclosed |
| US-20050256191-A1 | Nitroaniline-based alkylating agents and their use as prodrugs | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256191-A1 | Nitroaniline-based alkylating agents and their use as prodrugs | IDH3A, HIF1AN, IDH1 | ALDH1A1 325/4885KDM4E 1057/4885SMN1; SMN2 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.