Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778016 | 0.86 | PCSK9 (0.48) | PCSK9AGTR1L3MBTL1HTR6CYP19A1 | |
| SCHEMBL29778015 | 0.83 | PCSK9 (0.44) | PCSK9AGTR1L3MBTL1HTR6NOD2 | |
| SCHEMBL28400037 | 0.79 | AGTR1 (0.41) | PCSK9AGTR1L3MBTL1HTR6CYP19A1 | |
| SCHEMBL29778010 | 0.79 | AGTR1 (0.41) | PCSK9AGTR1L3MBTL1HTR6CYP19A1 | |
| SCHEMBL28402229 | 0.79 | PCSK9 (0.44) | PCSK9AGTR1L3MBTL1HTR6NOD1 | |
| SCHEMBL28397417 | 0.79 | HTR6 (0.42) | PCSK9AGTR1L3MBTL1HTR6CYP19A1 | |
| SCHEMBL28790159 | 0.78 | PCSK9 (0.48) | PCSK9AGTR1L3MBTL1HTR6NOD2 | |
| SCHEMBL28408113 | 0.76 | PCSK9 (0.46) | PCSK9AGTR1L3MBTL1HTR6NOD2 | |
| SCHEMBL29778014 | 0.76 | PCSK9 (0.46) | PCSK9AGTR1L3MBTL1HTR6NOD2 | |
| SCHEMBL28398527 | 0.75 | AGTR1 (0.45) | PCSK9AGTR1L3MBTL1HTR6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111187298-B | C2-phosphono methylene indole compound and preparation method and application thereof | 成都大学 | 2022-07-19 | — | — | CN | disclosed |